A Review on Novel Approach of Oral Drug Administration: Gastro Retentive Drug Delivery System
نویسندگان
چکیده
Over several centuries, oral dosage forms have remained incomparably superior to alternative medication delivery methods. For its ease of formulation and administration, stability, excellent rate patient compliance, the route is preferred. Gastric emptying has been a major drawback for drugs that stay very short period in stomach. An innovative method gastro-intestinal retention allows form gastrointestinal region longer maximize drug release. Gastro retentive system applied enhancing bioavailability, local action gastric region, maintaining steady concentrations minimising regimen. This review discusses approaches used gastro system, which include floating, high density, muco-adhesive, magnetic various other systems. Floating systems are most widely approach under system. These extensively because their simplicity. Drug content, hardness, particle size analysis, weight variation friability some conventional tests any form. Along with these, buoyancy studies, dissolution swelling index also carried out. Techniques like resonance imaging vivo evaluation. Yet, evaluating entire efficacy case small animals significant drawback. regarded as formulative strategy improve activity bioavailability active pharmaceutical ingredient based on benefits applications. It anticipated numerous more studies will uncover system's full potential.
منابع مشابه
gastro retentive drug delivery systems: a review
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2023
ISSN: ['0250-474X', '1998-3743']
DOI: https://doi.org/10.36468/pharmaceutical-sciences.1152